Literature data are not consistant about these changes and further studies are needed. It is believed that higher concentrations of estradiol and lower concentration of progesterone in the midluteal phase, their disbalance and changed ratio can be the key factor in etiology of FBD. The hormonal changes, predominantly in estradiol and progesterone, as well as growth factors like the epidermal growth factor (EGF) and tissue growth factor α (TGFα) are the key factors in understanding the development and etiology of FBD. The incidence of benign breast disease within a population is 13.5% to 42%. Received 1 March 2016 accepted 25 April 2016 published 28 April 2016įibrocystic breast disease (FBD) is a condition with high incidence in women during the reproductive age. Number and size of the cysts in patients with FBD. Mastalgia and mastodynia significantlyĭecreased during the local p gel therapy, and there was a significantly lower Number and size of the cysts (p < 0.001). Therapy, it was found decrease in pain and tension (p < 0.001), and the on 24th day before the therapy (p < 0.001). same day ofĮ2 level, before the therapy (p = 0.164). before the treatment p < 0.01, as wellĪs the decrease of E2 level on the 24th day during the therapy vs. There was a decreaseĮ2/P relation during the therapy vs. Wilcoxon test and Friedman test were used for statistics. The 21st and 24th day of a cycle, ultrasound measured size and number of cystsīefore and during the therapy. Women had (E2) and (P) concentration checked before and during the therapy on Information for mastalgia and mastodynia were checked with a questionnaire. The effect of progesterone therapy on E2/P ratio changesĭuring the luteal phase, and its consequences are on mastalgia and cyst, withinĪ fibrocystic breast disease (FBD).
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